Scalable Synthesis of β-Lactamase Inhibitor QPX7728 by Sequential Nickel-Catalyzed Boron Insertion into a Benzofuran Substrate and Enantioselective Cyclopropanation of the Resulting Vinylboronate-Reference-Cited by-同舟云学术

Scalable Synthesis of β-Lactamase Inhibitor QPX7728 by Sequential Nickel-Catalyzed Boron Insertion into a Benzofuran Substrate and Enantioselective Cyclopropanation of the Resulting Vinylboronate

Published:2021-09-15 Issue: Volume: Page:
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Boyer Serge H.¹,Gonzalez-de-Castro Angela²,Dielemans J.A. Hubertus²,Lefort Laurent²,Zhu Zuolin³,Gnahn Matthias⁴,Schörghuber Julia⁵,Steinhofer Stefan⁵,de Vries André H. M.²,Hecker Scott J.¹^ORCID

Affiliation:

1. Qpex Biopharma Inc., 6275 Nancy Ridge Drive, Suite 100, San Diego, California 92121, United States

2. Innosyn B.V., Urmonderbaan 22, 6167 RD Geleen, The Netherlands

3. Ampac Fine Chemicals, Highway 50 and Hazel Avenue, Rancho Cordova, California 95670, United States

4. Thermo Fisher Scientific Regensburg − ResCom, Donaustauferstraße 378, 93055 Regensburg, Germany

5. Thermo Fisher Scientific Austria, St.-Peter-Straße 25, 4020 Linz, Austria

Funder

Biomedical Advanced Research and Development Authority

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00285

Reference72 articles.

1. Antibiotic Resistance Mechanisms in Bacteria: Relationships Between Resistance Determinants of Antibiotic Producers, Environmental Bacteria, and Clinical Pathogens

2. Preserving the Dwindling β-lactams-Based Empiric Therapy Options for Gram-Negative Infections in Challenging Resistance Scenario: Lessons Learned and Way Forward

3. Cole, M.; Howarth, T. T.; Reading, C. (Beecham). US 4529720 A, 1974.

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