Enabling the Scale-Up of a Key Asymmetric Hydrogenation Step in the Synthesis of an API Using Continuous Flow Solid-Supported Catalysis-Reference-Cited by-同舟云学术

Enabling the Scale-Up of a Key Asymmetric Hydrogenation Step in the Synthesis of an API Using Continuous Flow Solid-Supported Catalysis

Published:2016-06-10 Issue:7 Volume:20 Page:1321-1327
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Amara Zacharias¹,Poliakoff Martyn¹,Duque Rubén²,Geier Daniel²,Franciò Giancarlo²,Gordon Charles M.³,Meadows Rebecca E.⁴,Woodward Robert⁴,Leitner Walter²

Affiliation:

1. The School of Chemistry, The University of Nottingham, Nottingham, NG7 2RD, United Kingdom

2. Institut für Technische und Makromolekulare Chemie ITMC, RWTH Aachen University, Worringerweg 2, 52074 Aachen, Germany

3. Britest Limited, The Heath Business & Technical Park, Runcorn WA7 4QX, United Kingdom

4. Pharmaceutical Development, AstraZeneca, Silk Road Business Park, Macclesfield, SK10 2NA, United Kingdom

Funder

Seventh Framework Programme

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.6b00143

Reference45 articles.

1. Continuous-Flow Technology-A Tool for the Safe Manufacturing of Active Pharmaceutical Ingredients

2. Deal, M.InNew Synthetic Technologies in Medicinal Chemistry;Farrant, E., Ed.The Royal Society of Chemistry, 2012; p90.

3. Practical Assessment Methodology for Converting Fine Chemicals Processes from Batch to Continuous

4. Pharmaceutical Roundtable Study Demonstrates the Value of Continuous Manufacturing in the Design of Greener Processes

5. Eco-efficiency Analysis for Intensified Production of an Active Pharmaceutical Ingredient: A Case Study

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