Development of a Zinc-Mediated Approach to a 2,3-cis-Pyrrolidine Arginase Inhibitor-Reference-Cited by-同舟云学术

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Development of a Zinc-Mediated Approach to a 2,3-cis-Pyrrolidine Arginase Inhibitor

Published:2020-06-09 Issue:8 Volume:24 Page:1457-1466
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Lyons Thomas W.¹^ORCID,Martinot Theodore A.¹,He Cyndi Qixin²,Qi Ji³^ORCID,Shao Guangxin⁴

Affiliation:

1. Department of Process Research and Development, Merck & Company, Inc., 33 Avenue Louis Pasteur, Boston, Massachusetts 02115, United States

2. Department Modeling and Informatics, Merck & Company, Inc., 90 E. Scott Avenue, Rahway, New Jersey 07065, United States

3. Department of Process Research and Development, Merck &Company, Inc., 126 E. Lincoln Avenue, Rahway, New Jersey 07065, United States

4. Department of Synthetic Chemistry, Pharmaron Beijing Company, Ltd., 6 Taihe Rd BDA, Beijing 100176, China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00171

Reference31 articles.

1. Catalysis By Metal-Activated Hydroxide in Zinc and Manganese Metalloenzymes

2. REGULATION OF ENZYMES OF THE UREA CYCLE AND ARGININE METABOLISM

3. Metabolism of L-Arginine by Myeloid-Derived Suppressor Cells in Cancer: Mechanisms of T cell suppression and Therapeutic Perspectives

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1. Proline Analogues;Chemical Reviews;2024-06-28

2. Palladium‐Catalyzed Tandem Cyclization Strategy for the Assembly of 3‐Halo ‐1,2,5‐triarylpyrroles from N ‐Alkylanilines and Haloalkynes;Chinese Journal of Chemistry;2022-12-10

3. Palladium-catalyzed oxidative C–H activation/annulation of N-alkylanilines with bromoalkynes: access to functionalized 3-bromoindoles;Chemical Communications;2022

4. Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors;ACS Medicinal Chemistry Letters;2021-10-13

5. Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology;ACS Medicinal Chemistry Letters;2021-07-16

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