Early Process Development of an Irreversible Epidermal Growth Factor Receptor (EGFR) T790 M Inhibitor-Reference-Cited by-同舟云学术

Early Process Development of an Irreversible Epidermal Growth Factor Receptor (EGFR) T790 M Inhibitor

Published:2019-01-31 Issue:3 Volume:23 Page:382-388
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Tao Yong¹^ORCID,Keene Nandell F.¹,Wiglesworth Kristin E.¹,Sitter Barbara¹,McWilliams J. Christopher¹^ORCID

Affiliation:

1. Chemical Research and Development, Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.8b00437

Reference17 articles.

1. Analysis of Tumor Specimens at the Time of Acquired Resistance to EGFR-TKI Therapy in 155 Patients with EGFR-Mutant Lung Cancers

2. Recent progress on third generation covalent EGFR inhibitors

3. aCheng, H.; Johnson, T. O., Jr.; Kath, J. C.; Liu, K. K.C.; Lunney, E. A.; Nagata, A.; Nair, S. K.; Planken, S. P.; Sutton, S. C. Preparation of pyrrolopyrimidine and purine derivatives for the treatment of abnormal cell growth. WO2013042006.

4. Discovery of 1-{(3R,4R)-3-[({5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}oxy)methyl]-4-methoxypyrrolidin-1-yl}prop-2-en-1-one (PF-06459988), a Potent, WT Sparing, Irreversible Inhibitor of T790M-Containing EGFR Mutants

5. Protection of imidazoles as their β-trimethylsilylethoxymethyl (SEM) derivatives

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