Process Research and Impurity Control Strategy for Obeticholic Acid, a Farnesoid X Receptor Agonist-Reference-Cited by-同舟云学术

Process Research and Impurity Control Strategy for Obeticholic Acid, a Farnesoid X Receptor Agonist

Published:2019-09-04 Issue:9 Volume:23 Page:1979-1989
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Feng Wei-Dong¹,Zhuo Song-Ming²,Zhang Fu-Li¹³^ORCID

Affiliation:

1. Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, 18 Chaowang Road, Hangzhou 310032, China

2. Department of Pharmaceutical Engineering, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China

3. Shanghai Institute of Pharmaceutical Industry, China State Institute of Pharmaceutical Industry, 285 Gebaini Road, Pudong, Shanghai 201203, China

Funder

Zhejiang University of Technology

China State Institute of Pharmaceutical Industry

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00252

Reference21 articles.

1. Obeticholic Acid in Primary Biliary Cholangitis

2. aPellicciari, R. Steroids as Agonists for FXR. PCT Int. Appl. WO02/072598, 2002.

3. 6α-Ethyl-Chenodeoxycholic Acid (6-ECDCA), a Potent and Selective FXR Agonist Endowed with Anticholestatic Activity

4. Ferrari, M.; Pellicciari, R. Process for Preparing 3α(β)-7α(β)-Dihydroxy-6α(β)-alkyl-5β-cholanic Acid. PCT Int. Appl. WO2006/122977, 2006.

5. Steiner, A.; Waenerlund Poulsen, H.; Jolibois, E. Preparation, Uses and Solid Forms of Obeticholic Acid. PCT Int. Appl. WO2013/192097, 2013.

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