Integrated Biocatalysis in Multistep Drug Synthesis without Intermediate Isolation: A de Novo Approach toward a Rosuvastatin Key Building Block-Reference-Cited by-同舟云学术

Integrated Biocatalysis in Multistep Drug Synthesis without Intermediate Isolation: A de Novo Approach toward a Rosuvastatin Key Building Block

Published:2015-06-01 Issue:6 Volume:19 Page:635-638
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Metzner Richard¹,Hummel Werner²,Wetterich Frank³,König Burghard⁴,Gröger Harald¹

Affiliation:

1. Faculty of Chemistry, Bielefeld University, Universitätsstr. 25, 33615 Bielefeld, Germany

2. Institute of Molecular Enzyme Technology, Jülich Research Center, Heinrich-Heine-University Düsseldorf, Stetternicher Forst, 52426 Jülich, Germany

3. Sandoz International GmbH, Industriestr. 18, 83607 Holzkirchen, Germany

4. Sandoz Industrial Products GmbH, Brüningstraße 50, 65929 Frankfurt am Main, Germany

Funder

Sandoz AG

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.5b00057

Reference26 articles.

1. Brooks, M. List of Top 100 Selling Drugs in 2013. Medscape Medical News, Jan 14, 2014; http://www.medscape.com/viewarticle/820011(accessed Feb 25, 2015).

2. Practical Synthesis of Chiral Synthons for the Preparation of HMG-CoA Reductase Inhibitors

3. Engineering the third wave of biocatalysis

4. Expanding the Enzyme Universe: Accessing Non-Natural Reactions by Mechanism-Guided Directed Evolution

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