Overcoming the Challenges of Making a Single Enantiomer N-1 Substituted Tetrazole Prodrug Using a Tin-Mediated Alkylation and Enzymatic Resolution-Reference-Cited by-同舟云学术

Overcoming the Challenges of Making a Single Enantiomer N-1 Substituted Tetrazole Prodrug Using a Tin-Mediated Alkylation and Enzymatic Resolution

Published:2019-05-09 Issue:6 Volume:23 Page:1167-1177
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Akin Anne,Barilla Mark T.,Brandt Thomas A.,Brennan John,Henegar Kevin E.,Hoagland Steve,Kumar Rajesh,Magano Javier,McInturff Emma L.^ORCID,Nematalla Asaad,Piotrowski David W.^ORCID,Van Haitsma Jared,Wei Liuqing,Xiao Jun,Yu Shu

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00104

Reference19 articles.

1. Efficacy and Safety of Alirocumab in Reducing Lipids and Cardiovascular Events

2. Efficacy and Safety of Evolocumab in Reducing Lipids and Cardiovascular Events

3. Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain

4. Small Molecule Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Inhibitors: Hit to Lead Optimization of Systemic Agents

5. A Scalable Route for the Regio- and Enantioselective Preparation of a Tetrazole Prodrug: Application to the Multi-Gram-Scale Synthesis of a PCSK9 Inhibitor

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