Synthesis of the Lipophilic Amine Tail of Abediterol Enabled by Multiphase Flow Transformations-Reference-Cited by-同舟云学术

Synthesis of the Lipophilic Amine Tail of Abediterol Enabled by Multiphase Flow Transformations

Published:2021-03-08 Issue:4 Volume:25 Page:947-959
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

García-Lacuna Jorge¹,Fleiß Tobias¹²,Munday Rachel³,Leslie Kevin³,O’Kearney-McMullan Anne³,Hone Christopher A.¹²^ORCID,Kappe C. Oliver¹²^ORCID

Affiliation:

1. Institute of Chemistry, University of Graz, NAWI Graz, Heinrichstrasse 28, A-8010 Graz, Austria

2. Center for Continuous Flow Synthesis and Processing (CCFLOW), Research Center Pharmaceutical Engineering GmbH (RCPE), Inffeldgasse 13, 8010 Graz, Austria

3. Chemical Development, Pharmaceutical Technology & Development, Operations, AstraZeneca, Macclesfield, United Kingdom

Funder

Bundesministerium f?r Verkehr, Innovation und Technologie

?sterreichische Forschungsf?rderungsgesellschaft

Bundesministerium f?r Digitalisierung und Wirtschaftsstandort

Styrian Funding Agency

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.1c00002

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4. Pharmacological Characterization of Abediterol, a Novel Inhaled β2-Adrenoceptor Agonist with Long Duration of Action and a Favorable Safety Profile in Preclinical Models

5. Marchueta Hereu, I.; Moyes Valls, E. Process for manufacturing 5-(2-{[6-(2,2-difluoro-2-penylethoxy)hexyl]amino}-1-hydroxyethyl)8-hydroxyquinolin-2(1H)-one. U.S. Patent, 2013, US 8,524.908 B2.

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