Development of a Safe and High-Throughput Continuous Manufacturing Approach to 4-(2-Hydroxyethyl)thiomorpholine 1,1-Dioxide-Reference-Cited by-同舟云学术

Development of a Safe and High-Throughput Continuous Manufacturing Approach to 4-(2-Hydroxyethyl)thiomorpholine 1,1-Dioxide

Published:2018-05-14 Issue:6 Volume:22 Page:721-727
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Strotman Neil A.¹^ORCID,Tan Yichen¹,Powers Kyle W.²,Soumeillant Maxime¹,Leung Simon W.²

Affiliation:

1. Chemical and Synthetic Development, Global Product Development, Bristol-Myers Squibb, One Squibb Drive, New Brunswick, New Jersey 08903, United States

2. Research and Development External Manufacturing, Global Product Development, Bristol-Myers Squibb, One Squibb Drive, New Brunswick, New Jersey 08903, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.8b00100

Reference9 articles.

1. Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity

2. Synthesis of HIV-Maturation Inhibitor BMS-955176 from Betulin by an Enabling Oxidation Strategy

3. 175. Syntheses of some β-chlorinated amines

4. Divinylsulfone has been classified as an acute toxin hazardous chemical by the European Chemicals Agency: https://echa.europa.eu/substance-information/-/substanceinfo/100.000.962.

5. Divinylsulfone has been deemed a hypertoxic chemical in China based on the following numeric cut-off criteria: Oral LD50 ≤ 5mg/kg bodyweight, or Dermal LD50 ≤ 50mg/kg bodyweight, or Inhalation LC50 ≤ 0.5 mg/L (vapor): http://www.chinasafety.gov.cn/newpage/Contents/Channel_5330/2015/0309/247023/content_247023.htm.

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