Synthesis of HIV-Maturation Inhibitor BMS-955176 from Betulin by an Enabling Oxidation Strategy-Reference-Cited by-同舟云学术

Synthesis of HIV-Maturation Inhibitor BMS-955176 from Betulin by an Enabling Oxidation Strategy

Published:2017-04-19 Issue:9 Volume:82 Page:4958-4963
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Ortiz Adrian¹^ORCID,Soumeillant Maxime¹,Savage Scott A.¹,Strotman Neil A.¹^ORCID,Haley Matthew¹,Benkovics Tamas¹,Nye Jeffrey¹,Xu Zhongmin¹,Tan Yichen¹,Ayers Sloan¹^ORCID,Gao Qi¹,Kiau Susanne¹

Affiliation:

1. Chemical and Synthetic Development, Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.7b00438

Reference20 articles.

1. HIV entry inhibitors and their potential in HIV therapy

2. Anti-AIDS Agents 81. Design, Synthesis, and Structure−Activity Relationship Study of Betulinic Acid and Moronic Acid Derivatives as Potent HIV Maturation Inhibitors

3. Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity

4. A Preliminary Pharmacokinetic Study of Betulin, the Main Pentacyclic Triterpene from Extract of Outer Bark of Birch (Betulae alba cortex)

5. Study of the betulin enriched birch bark extracts effects on human carcinoma cells and ear inflammation

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