Application of Chiral Transfer Reagents to Improve Stereoselectivity and Yields in the Synthesis of the Antituberculosis Drug Bedaquiline-Reference-Cited by-同舟云学术

Application of Chiral Transfer Reagents to Improve Stereoselectivity and Yields in the Synthesis of the Antituberculosis Drug Bedaquiline

Published:2023-10-13 Issue:11 Volume:27 Page:2146-2159
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Robey Juliana M. S.¹^ORCID,Maity Sanjay¹,Aleshire Sarah L.¹^ORCID,Ghosh Angshuman²,Yadaw Ajay K.²,Roy Subho²,Mear Sarah Jane³,Jamison Timothy F.³^ORCID,Sirasani Gopal⁴,Senanayake Chris H.⁴^ORCID,Stringham Rodger W.¹,Gupton B. Frank¹^ORCID,Donsbach Kai O.¹,Nelson Ryan C.¹,Shanahan Charles S.¹

Affiliation:

1. Medicines for All Institute, Virginia Commonwealth University, Richmond, Virginia 23284-3068, United States

2. R&D Centre, TCG Life Sciences Pvt. Limited, Kolkata, WB 700091, India

3. Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States

4. TCG GreenChem, Inc., Richmond, Virginia 23219, United States

Funder

Bill and Melinda Gates Foundation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.3c00287

Reference56 articles.

1. Treatment of Tuberculosis. A Historical Perspective

2. What We Know About Tuberculosis Transmission: An Overview

3. aWorld Health Organization Home Page https://www.who.int/news-room/fact-sheets/detail/tuberculosis (accessed April 18, 2023).

4. Covid-19’s Devastating Effect on Tuberculosis Care — A Path to Recovery

5. aPorstmann, F. R.; Horns, S.; Bader, T. Process for preparing (αS,βR)-6-bromo-α-[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-quinolineethanol. WO2006/125769A12006.

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