Interplay between Thermodynamics and Kinetics on Polymorphic Behavior of Vortioxetine Hydrobromide in Reactive Crystallization-Reference-Cited by-同舟云学术

Interplay between Thermodynamics and Kinetics on Polymorphic Behavior of Vortioxetine Hydrobromide in Reactive Crystallization

Published:2020-06-02 Issue:7 Volume:24 Page:1233-1243
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Cao Yun¹²,Du Shichao¹²^ORCID,Ke Xiao³,Xu Shijie⁴^ORCID,Lan Yangshan³,Zhang Teng¹²,Tang Weiwei¹²^ORCID,Wang Jingkang¹²,Gong Junbo¹²^ORCID

Affiliation:

1. School of Chemical Engineering and Technology, State Key Laboratory of Chemical Engineering, Tianjin University, Tianjin 300072, China

2. Key Laboratory Modern Drug Delivery and High Efficiency in Tianjin, Tianjin 300072, China

3. Chengdu Kanghong Pharmaceutical Group Co., Ltd., Sichuan 610036, China

4. Tianjin Key Laboratory of Marine Resources and Chemistry, College of Chemical Engineering and Materials Science, Tianjin University of Science and Technology, Tianjin 300457, China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00384

Reference46 articles.

1. Solvent-mediated phase transformation between two tegafur polymorphs in several solvents

2. Significance of controlling crystallization mechanisms and kinetics in pharmaceutical systems

3. Vortioxetine for the treatment of major depression

4. Bang-Andersen, B.; Faldt, A.; Mork, A.; Diego, H. L.; Holm, R.; Stensbol, T. B.; Moore, N. 1-[2-(2,4-Dimethylphenylsulfanyl)-phenyl] piperazine as A Compound with Combined Serotonin Reuptake, 5-HT3 and 5-HT1A Activity for the Treatment of Cognitive Impairment. US2014143267252014.

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