Development of a Gram-Scale Synthesis of PBRM, an Irreversible Inhibitor of 17β-Hydroxysteroid Dehydrogenase Type 1-Reference-Cited by-同舟云学术

Development of a Gram-Scale Synthesis of PBRM, an Irreversible Inhibitor of 17β-Hydroxysteroid Dehydrogenase Type 1

Published:2019-09-19 Issue:11 Volume:23 Page:2323-2335
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Maltais René¹,Poirier Donald¹²^ORCID

Affiliation:

1. Laboratory of Medicinal Chemistry, Endocrinology and Nephrology Unit, CHU de Québec—Research Center (CHUL, T4-42), 2705 Laurier Boulevard, Québec, Québec G1V 4G2, Canada

2. Department of Molecular Medicine, Faculty of Medicine, Université Laval, Québec, Québec G1V 0A6, Canada

Funder

Canadian Institutes of Health Research

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.8b00402

Reference42 articles.

1. Crucial Role of 3-Bromoethyl in Removing the Estrogenic Activity of 17β-HSD1 Inhibitor 16β-(m-Carbamoylbenzyl)estradiol

2. Discovery of a Non-Estrogenic Irreversible Inhibitor of 17β-Hydroxysteroid Dehydrogenase Type 1 from 3-Substituted-16β-(m-carbamoylbenzyl)-estradiol Derivatives

3. The key role of 17β-hydroxysteroid dehydrogenases in sex steroid biology

4. Analysis and characteristics of multiple types of human 17β-hydroxysteroid dehydrogenase

5. The regulation and inhibition of 17β-hydroxysteroid dehydrogenase in breast cancer

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