Multigram Synthesis of BMS-929075, an Allosteric, Palm Site Inhibitor of HCV NS5B Replicase, Involving the Synthesis of a Highly Functionalized Benzofuran through a Telescoped Process-Reference-Cited by-同舟云学术

Multigram Synthesis of BMS-929075, an Allosteric, Palm Site Inhibitor of HCV NS5B Replicase, Involving the Synthesis of a Highly Functionalized Benzofuran through a Telescoped Process

Published:2020-05-27 Issue:6 Volume:24 Page:1157-1163
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Smith Daniel¹,Krishnananthan Subramaniam¹,Meanwell Nicholas A.¹^ORCID,Mathur Arvind¹,Li Jianqing²^ORCID

Affiliation:

1. Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, P.O. Box 4000, Princeton, New Jersey 08543-4000, United States

2. Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development, 100 Binney Street, Cambridge, Massachusetts 02142, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00198

Reference17 articles.

1. Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies

2. Burns, C. J.; Del Vecchio, A. M.; Bailey, T. R.; Kulkarni, B. A.; Faitg, T. H.; Sherk, S. R.; BlackLedge, C. W.; Rys, D. J.; Lessen, T. A.; Swestock, J.; Deng, Y.; Nitz, T. J.; Reinhardt, J. A.; Feng, H.; Saha, A. K. Benzofuran compounds, compositions and methods for treatment and prophylaxis of hepatitis C viral infections and associated diseases. WO Patent WO2004/041201 A22004.

3. Useful Synthesis of Coumestans

4. A general method for the synthesis of isatins: Preparation of regiospecifically functionalized isatins from anilines

5. Total Synthesis of Nigellicine and Nigeglanine Hydrobromide

Cited by 10 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Chemoselective α-Trifluoroacetylation of Amides Using Highly Electrophilic Trifluoroacetic Anhydrides and 2,4,6-Collidine;Organic Letters;2023-12-04

2. Quinoline Alkaloids from the Roots of Orixa japonica with the Anti‐Pathogenic Fungi Activities;Chemistry & Biodiversity;2023-01-23

3. Synthesis of Furans via Rhodium(III)-Catalyzed Cyclization of Acrylic Acids with α-Diazocarbonyl Compounds;The Journal of Organic Chemistry;2022-08-29

4. Large-Scale Amidations in Process Chemistry: Practical Considerations for Reagent Selection and Reaction Execution;Organic Process Research & Development;2022-06-07

5. Recent Applications of Pd-Catalyzed Suzuki–Miyaura and Buchwald–Hartwig Couplings in Pharmaceutical Process Chemistry;Organics;2022-01-18