Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies-Reference-Cited by-同舟云学术

Discovery of a Hepatitis C Virus NS5B Replicase Palm Site Allosteric Inhibitor (BMS-929075) Advanced to Phase 1 Clinical Studies

Published:2017-05-04 Issue:10 Volume:60 Page:4369-4385
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Yeung Kap-Sun¹^ORCID,Beno Brett R.¹,Parcella Kyle¹,Bender John A.¹,Grant-Young Katherine A.¹,Nickel Andrew¹,Gunaga Prashantha²,Anjanappa Prakash²,Bora Rajesh Onkardas²,Selvakumar Kumaravel²,Rigat Karen¹,Wang Ying-Kai¹,Liu Mengping¹,Lemm Julie¹,Mosure Kathy¹,Sheriff Steven³,Wan Changhong³,Witmer Mark³,Kish Kevin³,Hanumegowda Umesh¹,Zhuo Xiaoliang¹,Shu Yue-Zhong³,Parker Dawn¹,Haskell Roy¹,Ng Alicia³,Gao Qi⁴,Colston Elizabeth³,Raybon Joseph³,Grasela Dennis M.³,Santone Kenneth¹,Gao Min¹,Meanwell Nicholas A.¹,Sinz Michael¹,Soars Matthew G.¹,Knipe Jay O.¹,Roberts Susan B.¹,Kadow John F.¹

Affiliation:

1. Bristol-Myers Squibb Research and Development, P.O. Box 5100, 5 Research Parkway, Wallingford, Connecticut 06492, United States

2. Department of Discovery Chemistry, Biocon Bristol-Myers Squibb Research and Development Center, Biocon Park, Jigani Link Road, Bommasandra IV, Bangalore 560099, India

3. Bristol-Myers Squibb Research and Development, P.O. Box 4000, Princeton, New Jersey 08543, United States

4. Bristol-Myers Squibb Research and Development, 1 Squibb Drive, New Brunswick, New Jersey 08901, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.7b00328

Reference63 articles.

1. WHO Hepatitis C Fact Sheet No. 164, http://www.who.int/mediacentre/factsheets/fs164/en/(updated July 2016; accessed February 5, 2017) .

2. Centers for Diseases Control and Prevention: Viral Hepatitis - Hepatitis C Information,http://www.cdc.gov/hepatitis/hcv/hcvfaq.htm(updated January 27, 2017; accessed February 5, 2017) .

3. Isolation of a cDNA cLone Derived from a Blood-Borne Non-A, Non-B Viral Hepatitis Genome

4. Expanded classification of hepatitis C virus into 7 genotypes and 67 subtypes: Updated criteria and genotype assignment web resource

5. Understanding the hepatitis C virus life cycle paves the way for highly effective therapies

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