An Evaluation of Multiple Catalytic Systems for the Cyanation of 2,3-Dichlorobenzoyl Chloride: Application to the Synthesis of Lamotrigine-Reference-Cited by-同舟云学术

An Evaluation of Multiple Catalytic Systems for the Cyanation of 2,3-Dichlorobenzoyl Chloride: Application to the Synthesis of Lamotrigine

Published:2017-10-31 Issue:11 Volume:21 Page:1815-1821
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Leitch David C.¹^ORCID,John Matthew P.²,Slavin Paul A.³,Searle Andrew D.³

Affiliation:

1. Chemical Catalysis Group, API Chemistry, GlaxoSmithKline, King of Prussia, PA 19101, United States

2. High-Throughput Chemistry Group, API Chemistry, GlaxoSmithKline, Stevenage, U.K.

3. Global Manufacturing and Supply, GlaxoSmithKline, Stevenage, U.K.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.7b00262

Reference27 articles.

1. Baxter, M. G.; Elphick, A. R.; Miller, A. A.; Sawyer, D. A.1,2,4-Triazine Derivatives, Pharmaceutical Compositions and Intermediates Utilized for their Preparation. EP 21121, January 7, 1981.

2. aPubChem Compound Summary for Lamotrigine (National Center for Biotechnology Information).https://pubchem.ncbi.nlm.nih.gov/compound/3878(accessed September 13, 2016) .

3. Studies on the mechanism of action of the novel anticonvulsant lamotrigine (Lamictal) using primary neuroglial cultures from rat cortex

4. Lamotrigine

5. The neurobiology of antiepileptic drugs

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