Incorporation of an Intramolecular Hydrogen-Bonding Motif in the Side Chain of 4-Aminoquinolines Enhances Activity against Drug-Resistant P. falciparum-Reference-Cited by-同舟云学术

Incorporation of an Intramolecular Hydrogen-Bonding Motif in the Side Chain of 4-Aminoquinolines Enhances Activity against Drug-Resistant P. falciparum

Published:2006-06-27 Issue:15 Volume:49 Page:4535-4543
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Madrid Peter B.¹,Liou Ally P.¹,DeRisi Joseph L.¹,Guy R. Kiplin¹

Affiliation:

1. Department of Pharmaceutical Chemistry, Department of Biochemistry and Biophysics, and Department of Cellular and Molecular Pharmacology, University of California, San Francisco, California 94143-2280

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0600951

Reference29 articles.

1. Effectiveness of Antimalarial Drugs

2. The economic and social burden of malaria

3. Chloroquine Resistance in Plasmodium falciparum Malaria Parasites Conferred by pfcrt Mutations

4. Mefloquine resistance in Plasmodium falciparum and increased pfmdr1 gene copy number

5. 4-aminoquinoline analogs of chloroquine with shortened side chains retain activity against chloroquine-resistant Plasmodium falciparum

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