Quinoline Containing Side-chain Antimalarial Analogs: Recent Advances and Therapeutic Application-Reference-Cited by-同舟云学术

Quinoline Containing Side-chain Antimalarial Analogs: Recent Advances and Therapeutic Application

Published:2020-04-25 Issue:8 Volume:20 Page:617-697
ISSN:1568-0266
Container-title:Current Topics in Medicinal Chemistry
language:en
Short-container-title:CTMC

Author:

Joshi Mukesh C.¹,Egan Timothy J.²

Affiliation:

1. Department of Chemistry, Motilal Nehru College, Benito Juarez Marg, South Campus, University of Delhi, New Delhi- 110021, India

2. Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa

Abstract

The side-chains of quinoline antimalarial agents are the major concern of focus to build novel and efficaciaous bioactive and clinical antimalarials. Bioative antimalarial analogs may play a critical role in pH trapping in the food vacuole of RBC’s with the help of fragmented amino acid, thus lead to β-hematin inhibition. Here, the authors tried to summarize a useful, comprehensive compilation of side-chain modified ACQs along with their synthesis, biophysical and therapeutic applications etc. of potent antiplasmodial agents and therefore, opening the door towards the potential clinical status.

Publisher

Bentham Science Publishers Ltd.

Subject

Drug Discovery,General Medicine

Reference210 articles.

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