Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 6. Study of the 5-HT1A/α1-Adrenergic Receptor Affinity by Classical Hansch Analysis, Artificial Neural Networks, and Computational Simulation of Ligand Recognition-Reference-Cited by-同舟云学术

Synthesis and Structure−Activity Relationships of a New Model of Arylpiperazines. 6. Study of the 5-HT1A/α1-Adrenergic Receptor Affinity by Classical Hansch Analysis, Artificial Neural Networks, and Computational Simulation of Ligand Recognition

Published:2000-12-22 Issue:2 Volume:44 Page:198-207
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

López-Rodríguez María L.¹,Morcillo M. José¹,Fernández Esther¹,Rosado M. Luisa¹,Pardo Leonardo¹,Schaper Klaus-Jürgen¹

Affiliation:

1. Departamento de Química Orgánica I, Facultad de Ciencias Químicas, Universidad Complutense, 28040 Madrid, Spain, Facultad de Ciencias, Universidad Nacional de Educación a Distancia, 28040 Madrid, Spain, Laboratori de Medicina Computacional, Unitat de Bioestadística, Facultat de Medicina, Universitat Autonoma de Barcelona, 08193 Bellaterra, Spain, and Research Center Borstel, D-23845 Borstel, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm000930t

Reference39 articles.

1. Deoxyribonucleoside-3′,5′ Cyclic Phosphates. Synthesis and Acid-Catalyzed and Enzymic Hydrolysis

2. Applications of neural networks in quantitative structure-activity relationships of dihydrofolate reductase inhibitors

Cited by 69 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Insights of ligand binding in modeled h5-HT1A receptor: homology modeling, docking, MM-GBSA, screening and molecular dynamics;Journal of Biomolecular Structure and Dynamics;2021-08-13

2. Prediction of anti-HIV activity on the basis of stacked auto-encoder;Journal of Chemometrics;2017-07-18

3. From Homology Models to a Set of Predictive Binding Pockets–a 5-HT1A Receptor Case Study;Journal of Chemical Information and Modeling;2017-01-18

4. Intramolecular Cyclization Side Reactions;Side Reactions in Peptide Synthesis;2016

5. Synthesis, preclinical evaluation and molecular modelling of macrocyclic appended 1-(2-methoxyphenyl)piperazine for 5-HT1A neuroreceptor imaging;RSC Advances;2016