Precise Introduction of the −CHnX3–n (X = F, Cl, Br, I) Moiety to Target Molecules by a Radical Strategy: A Theoretical and Experimental Study

Author:

Liu Siqi12,Su Yong-Liang3,Sun Tian-Yu2,Doyle Michael P.3ORCID,Wu Yun-Dong124ORCID,Zhang Xinhao24ORCID

Affiliation:

1. College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China

2. Shenzhen Bay Laboratory, Shenzhen, 518132, China

3. Department of Chemistry, The University of Texas at San Antonio, San Antonio, Texas 78249, United States

4. Lab of Computational Chemistry and Drug Design, State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Shenzhen 518055, China

Funder

Welch Foundation

National Natural Science Foundation of China

Shenzhen Municipal Health Commission

Guangdong Province

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Reference81 articles.

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2. Potential antimalarials. 7. Tribromomethylquinolines and positive halogen compounds

3. Identification of Clinically Viable Quinolinol Inhibitors of Botulinum Neurotoxin A Light Chain

4. Sato, S.; Thiazolidine Derivatives as Chymase Inhibitors and Prophylactic and Therapeutic Drugs Containing Them for Cardiovascular Diseases. Patent JP2000095770A, 2000.

5. Shaw, A. T.; Jacks, T. E.; Tolliday, N. Tolperisone and Tolperisone-Like Drugs for the Treatment of K-Ras Associated Cancers. Patent WO2009038771A2, 2009.

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