Turnover and Inactivation Mechanisms for (S)-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase-Reference-Cited by-同舟云学术

Turnover and Inactivation Mechanisms for (S)-3-Amino-4,4-difluorocyclopent-1-enecarboxylic Acid, a Selective Mechanism-Based Inactivator of Human Ornithine Aminotransferase

Published:2021-06-07 Issue:23 Volume:143 Page:8689-8703
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Shen Sida¹^ORCID,Butrin Arseniy²,Doubleday Peter F.³,Melani Rafael D.³,Beaupre Brett A.²,Tavares Mauricio T.⁴,Ferreira Glaucio M.⁵^ORCID,Kelleher Neil L.¹³^ORCID,Moran Graham R.²^ORCID,Liu Dali²^ORCID,Silverman Richard B.¹³⁶^ORCID

Affiliation:

1. Department of Chemistry, Center for Molecular Innovation and Drug Discovery, and Center for Developmental Therapeutics, Northwestern University, Evanston, Illinois 60208, United States

2. Department of Chemistry and Biochemistry, Loyola University Chicago, Chicago, Illinois 60660, United States

3. Department of Molecular Biosciences, Northwestern University, Evanston, Illinois 60208, United States

4. Department of Molecular Medicine, Scripps Research, Jupiter, Florida 33458, United States

5. Department of Clinical and Toxicological Analyses, School of Pharmaceutical Sciences, University of São Paulo, São Paulo, SP 05508-000, Brazil

6. Department of Pharmacology, Northwestern University, Chicago, Illinois 60611, United States

Funder

Funda????o de Amparo ?? Pesquisa do Estado de S??o Paulo

U.S. Department of Health and Human Services

National Science Foundation

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.1c02456

Reference34 articles.

1. Ornithine Aminotransferase versus GABA Aminotransferase: Implications for the Design of New Anticancer Drugs

2. The Proline Cycle As a Potential Cancer Therapy Target

3. Global Metabolic Profiling Identifies a Pivotal Role of Proline and Hydroxyproline Metabolism in Supporting Hypoxic Response in Hepatocellular Carcinoma

4. New targets of β-catenin signaling in the liver are involved in the glutamine metabolism

5. Hepatocellular carcinoma

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