Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain-Reference-Cited by-同舟云学术

Discovery of MK-4409, a Novel Oxazole FAAH Inhibitor for the Treatment of Inflammatory and Neuropathic Pain

Published:2014-04-14 Issue:6 Volume:5 Page:717-721
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Chobanian Harry R.¹,Guo Yan¹,Liu Ping¹,Chioda Marc D.¹,Fung Selena¹,Lanza Thomas J.¹,Chang Linda¹,Bakshi Raman K.¹,Dellureficio James P.¹,Hong Qingmei¹,McLaughlin Mark¹,Belyk Kevin M.¹,Krska Shane W.¹,Makarewicz Amanda K.¹,Martel Elliot J.¹,Leone Joseph F.¹,Frey Lisa¹,Karanam Bindhu¹,Madeira Maria¹,Alvaro Raul¹,Shuman Joyce¹,Salituro Gino¹,Terebetski Jenna L.¹,Jochnowitz Nina¹,Mistry Shruti¹,McGowan Erin¹,Hajdu Richard¹,Rosenbach Mark¹,Abbadie Catherine¹,Alexander Jessica P.¹,Shiao Lin-Lin¹,Sullivan Kathleen M.¹,Nargund Ravi P.¹,Wyvratt Matthew J.¹,Lin Linus S.¹,DeVita Robert J.¹

Affiliation:

1. Departments of Medicinal Chemistry, ‡Process Chemistry, §Drug Metabolism and Pharmacokinetics, ∥Preclinical Development, ⊥Pharmacology, and ○Immunology, Merck Research Laboratories, Kenilworth, New Jersey 07033, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml5001239

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4. Supersensitivity to anandamide and enhanced endogenous cannabinoid signaling in mice lacking fatty acid amide hydrolase

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