Design, Synthesis, and Biological Evaluation of 1-[(2-Benzyloxyl/alkoxyl)methyl]-5-halo-6-aryluracils as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with an Improved Drug Resistance Profile-Reference-Cited by-同舟云学术

Design, Synthesis, and Biological Evaluation of 1-[(2-Benzyloxyl/alkoxyl)methyl]-5-halo-6-aryluracils as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with an Improved Drug Resistance Profile

Published:2012-02-17 Issue:5 Volume:55 Page:2242-2250
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wang Xiaowei,Zhang Jianfang¹,Huang Yang²,Wang Ruiping¹,Zhang Liang,Qiao Kang,Li Li,Liu Chang¹,Ouyang Yabo²,Xu Weisi²,Zhang Zhili,Zhang Liangren,Shao Yiming²,Jiang Shibo³,Ma Liying²,Liu Junyi

Affiliation:

1. College of Pharmaceutical Sciences, Capital Medical University, Beijing 100069

2. State Key Laboratory for Infection Disease Prevention and Control, National Center for AIDS/STD Control and Prevention (NCAIDS), Chinese Center for Disease Control and Prevention, Beijing 102206

3. MOE/MOH Key Laboratory of Medical Molecular Virology, Shanghai Medical College and Institute of Medical Microbiology, Fudan University, Shanghai 200032, China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm201506e

Reference38 articles.

1. Nonnucleoside Inhibitors of HIV-1 Reverse Transcriptase: from the Biology of Reverse Transcription to Molecular Design

2. Recent Advances in the Development of Next Generation Non-nucleoside Reverse Transcriptase Inhibitors

3. Conformational Changes in HIV-1 Reverse Transcriptase Induced by Nonnucleoside Reverse Transcriptase Inhibitor Binding

4. New developments in anti-HIV chemotherapy

5. High resolution structures of HIV-1 RT from four RT–inhibitor complexes

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