1. Institute of Biochemical and Biomedical Engineering, Biomedical Engineering Research Center, and Molecular Medicine Research Center, Chang Gung University, Taoyuan, Taiwan 33302, Republic of China, Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan 11217, Republic of China, and Department of Chemical Engineering, National Tsing Hua University, Hsinchu, Taiwan 30013, Republic of China