Bedaquiline and Pyrazinamide Treatment Responses Are Affected by Pulmonary Lesion Heterogeneity in Mycobacterium tuberculosis Infected C3HeB/FeJ Mice

Author:

Irwin Scott M.1,Prideaux Brendan2,Lyon Edward R.1,Zimmerman Matthew D.2,Brooks Elizabeth J.1,Schrupp Christopher A.1,Chen Chao2,Reichlen Matthew J.3,Asay Bryce C.1,Voskuil Martin I.3,Nuermberger Eric L.4,Andries Koen5,Lyons Michael A.1,Dartois Véronique2,Lenaerts Anne J.1

Affiliation:

1. Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado 80523, United States

2. Public Health Research Institute, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, New Jersey 07103, United States

3. Department of Immunology and Microbiology, University of Colorado School of Medicine, Aurora, Colorado 80045, United States

4. Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, United States

5. Department of Infectious Diseases, Janssen Pharmaceutica, 2340 Beerse, Belgium

Funder

Bill and Melinda Gates Foundation

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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