A Series of Spiropyrimidinetriones that Enhances DNA Cleavage Mediated by <i>Mycobacterium tuberculosis</i> Gyrase-Reference-Cited by-同舟云学术

A Series of Spiropyrimidinetriones that Enhances DNA Cleavage Mediated by Mycobacterium tuberculosis Gyrase

Published:2023-02-21 Issue:3 Volume:9 Page:706-715
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Byl Jo Ann W.¹,Mueller Rudolf²,Bax Ben³^ORCID,Basarab Gregory S.²^ORCID,Chibale Kelly²⁴^ORCID,Osheroff Neil¹⁵⁶^ORCID

Affiliation:

1. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States

2. Drug Discovery and Development Centre (H3D), Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa

3. Medicines Discovery Institute, Cardiff University, Cardiff CF10 3AT, United Kingdom

4. South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa

5. Medicine (Hematology/Oncology), Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States

6. VA Tennessee Valley Healthcare System, Nashville, Tennessee 37212, United States

Funder

U.S. Department of Veterans Affairs

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation

University of Cape Town

National Institute of General Medical Sciences

South African Medical Research Council

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.3c00012

Reference48 articles.

1. Mechanism of Quinolone Action and Resistance

2. DNA Topoisomerases

3. Topoisomerase Inhibitors: Fluoroquinolone Mechanisms of Action and Resistance

4. Bacterial Type II Topoisomerases and Target-Mediated Drug Resistance

5. DNA Topoisomerase Inhibitors: Trapping a DNA-Cleaving Machine in Motion

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