Interactions between Gepotidacin and <i>Escherichia coli</i> Gyrase and Topoisomerase IV: Genetic and Biochemical Evidence for Well-Balanced Dual-Targeting-Reference-Cited by-同舟云学术

Interactions between Gepotidacin and Escherichia coli Gyrase and Topoisomerase IV: Genetic and Biochemical Evidence for Well-Balanced Dual-Targeting

Published:2024-03-05 Issue:4 Volume:10 Page:1137-1151
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Oviatt Alexandria A.¹^ORCID,Gibson Elizabeth G.¹²^ORCID,Huang Jianzhong³,Mattern Karen³,Neuman Keir C.⁴,Chan Pan F.³,Osheroff Neil¹⁵⁶^ORCID

Affiliation:

1. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States

2. Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States

3. Infectious Diseases Research Unit, GlaxoSmithKline, Collegeville, Pennsylvania 19426, United States

4. Laboratory of Single Molecule Biophysics, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland 20982, United States

5. Department of Medicine (Hematology/Oncology), Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States

6. VA Tennessee Valley Healthcare System, Nashville, Tennessee 37212, United States

Funder

National Cancer Institute

U.S. Department of Veterans Affairs

National Institute of Allergy and Infectious Diseases

Division of Intramural Research

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.3c00346

Reference113 articles.

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2. World Health Organization Advisory Group on Integrated Surveillance of Antimicrobial Resistance. Critically important antimicrobials for human medicine: ranking of medically important antimicrobials for risk management of antimicrobial resistance due to non-human use; 2018. https://apps.who.int/iris/bitstream/handle/10665/312266/9789241515528-eng.pdf (accessed Jan 31, 2024).

3. Quinolones: Action and Resistance Updated

4. Origins and Evolution of Antibiotic Resistance

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