Strigolactones as Broad-Spectrum Antivirals against β-Coronaviruses through Targeting the Main Protease Mpro

Author:

Biolatti Matteo1ORCID,Blangetti Marco2ORCID,Baggieri Melissa3,Marchi Antonella3,Gioacchini Silvia3,Bajetto Greta14,Arnodo Davide2ORCID,Bucci Paola3,Fioravanti Raoul3ORCID,Kojouri Maedeh3,Bersani Matteo5,D’Arrigo Giulia5,Siragusa Lydia67ORCID,Ghinato Simone2,De Andrea Marco14,Gugliesi Francesca1,Albano Camilla1ORCID,Pasquero Selina1ORCID,Visentin Ivan8,D’Ugo Emilio3,Esposito Francesca9,Malune Paolo9,Tramontano Enzo9ORCID,Prandi Cristina2ORCID,Spyrakis Francesca5ORCID,Magurano Fabio3,Dell’Oste Valentina1ORCID

Affiliation:

1. Department of Public Health and Pediatric Sciences, University of Turin, 10126 Turin, Italy

2. Department of Chemistry, University of Turin, 10125 Turin, Italy

3. Department of Infectious Diseases, Istituto Superiore di Sanità, 00161 Rome, Italy

4. Center for Translational Research on Autoimmune and Allergic Disease-CAAD, 28100 Novara, Italy

5. Department of Drug Science and Technology, University of Turin, 10125 Turin, Italy

6. Molecular Discovery Ltd., Kinetic Business Centre, Elstree, Borehamwood, WD6 4PJ Hertfordshire, United Kingdom

7. Molecular Horizon s.r.l., 06084 Bettona (PG), Italy

8. Department of Agricultural, Forestry, and Food Sciences, University of Turin, 10095 Grugliasco, Turin, Italy

9. Department of Life and Environmental Sciences, University of Cagliari, 09042 Monserrato, Cagliari, Italy

Funder

Università degli Studi di Torino

Fondazione CRT

Ministero dell'Università e della Ricerca

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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