Author:
Xiong Hua-Long,Cao Jia-Li,Shen Chen-Guang,Ma Jian,Qiao Xiao-Yang,Shi Tian-Shu,Ge Sheng-Xiang,Ye Hui-Ming,Zhang Jun,Yuan Quan,Zhang Tian-Ying,Xia Ning-Shao
Abstract
To identify drugs that are potentially used for the treatment of COVID-19, the potency of 1403 FDA-approved drugs were evaluated using a robust pseudovirus assay and the candidates were further confirmed by authentic SARS-CoV-2 assay. Four compounds, Clomiphene (citrate), Vortioxetine, Vortioxetine (hydrobromide) and Asenapine (hydrochloride), showed potent inhibitory effects in both pseudovirus and authentic virus assay. The combination of Clomiphene (citrate), Vortioxetine and Asenapine (hydrochloride) is much more potent than used alone, with IC50 of 0.34 μM.
Funder
National Natural Science Foundation of China
Science, Technology and Innovation Commission of Shenzhen Municipality
Subject
Pharmacology (medical),Pharmacology
Cited by
23 articles.
订阅此论文施引文献
订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献