Sphingosine Kinases Promote Ebola Virus Infection and Can Be Targeted to Inhibit Filoviruses, Coronaviruses, and Arenaviruses Using Late Endocytic Trafficking to Enter Cells

Author:

Stewart Corina M.123ORCID,Bo Yuxia123,Fu Kathy123,Chan Mable45,Kozak Robert4,Apperley Kim Yang-Ping67,Laroche Geneviève123,Daniel Redaet123,Beauchemin André M.67,Kobinger Gary8,Kobasa Darwyn45,Côté Marceline1236ORCID

Affiliation:

1. Department of Biochemistry, Microbiology and Immunology, University of Ottawa, Ottawa, ON K1H 8L1, Canada

2. Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, ON K1H 8L1, Canada

3. Centre for Infection, Immunity, and Inflammation, University of Ottawa, Ottawa, ON K1H 8L1, Canada

4. Special Pathogens Program, National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, MB R3E 3R2, Canada

5. Department of Infectious Diseases and Medical Microbiology, University of Manitoba, Winnipeg, MB R3E 0J9, Canada

6. Center for Catalysis Research and Innovation, University of Ottawa, Ottawa, ON K1H 8L1, Canada

7. Department of Chemistry and Biomolecular Sciences, University of Ottawa, Ottawa, ON K1N 6N5, Canada

8. Galveston National Laboratory, Department of Microbiology & Immunology, University of Texas Medical Branch, Galveston, Texas 77550, United States

Funder

Government of Canada

University of Ottawa

Public Health Agency of Canada

Canada Research Chairs

Ontario Ministry of Research, Innovation and Science

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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