Structure–Activity Relationships of Spectinamide Antituberculosis Agents: A Dissection of Ribosomal Inhibition and Native Efflux Avoidance Contributions

Author:

Liu Jiuyu1,Bruhn David F.1,Lee Robin B.1,Zheng Zhong1,Janusic Tanja2,Scherbakov Dimitri2,Scherman Michael S.3,Boshoff Helena I.4,Das Sourav1,Rakesh 1,Waidyarachchi Samanthi L.1,Brewer Tiffany A.15,Gracia Begoña6,Yang Lei1,Bollinger John1,Robertson Gregory T.3,Meibohm Bernd5,Lenaerts Anne J.3,Ainsa Jose6,Böttger Erik C.2,Lee Richard E.1

Affiliation:

1. Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, MS#1000, Memphis, Tennessee 38105, United States

2. Institut für Medizinische Mikrobiologie, Nationales Zentrum für Mykobakterien, Universität Zürich, Rämistrasse 71, Gloriastrasse 30/32, CH-8006 Zürich, Switzerland

3. Mycobacterial Research Laboratories, Department of Microbiology, Colorado State University, 1682 Campus Delivery, Fort Collins, Colorado 80523, United States

4. Tuberculosis Research Section, Laboratory of Clinical Infectious Diseases, National Institute for Allergy and Infectious Disease, National Institutes of Health, 33 North Drive, Bethesda, Maryland 20814, United States

5. Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, 881 Madison Avenue, Memphis, Tennessee 38163, United States

6. Departamento de Microbiologı́a, Medicina Preventiva y Salud Pública, and BIFI, Universidad de Zaragoza and CIBER Enfermedades Respiratorias (CIBERES), 50009 Zaragoza, Spain

Funder

NIH Office of the Director

National Institute of Allergy and Infectious Diseases

American Lebanese Syrian Associated Charities

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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