Structure–Activity Relationships of the MEPicides: N-Acyl and O-Linked Analogs of FR900098 as Inhibitors of Dxr from Mycobacterium tuberculosis and Yersinia pestis-Reference-Cited by-同舟云学术

Structure–Activity Relationships of the MEPicides: N-Acyl and O-Linked Analogs of FR900098 as Inhibitors of Dxr from Mycobacterium tuberculosis and Yersinia pestis

Published:2016-10-12 Issue:12 Volume:2 Page:923-935
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

San Jose Géraldine¹,Jackson Emily R.¹,Haymond Amanda²,Johny Chinchu²,Edwards Rachel L.³,Wang Xu¹,Brothers R. Carl¹,Edelstein Emma K.¹,Odom Audrey R.³,Boshoff Helena I.⁴,Couch Robin D.²,Dowd Cynthia S.¹

Affiliation:

1. Department of Chemistry, George Washington University, 800 22nd Street NW, Washington D.C. 20052, United States

2. Department of Chemistry and Biochemistry, George Mason University, 10900 University Boulevard, Manassas, Virginia 20110, United States

3. Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Avenue, St. Louis, Missouri 63110, United States

4. Tuberculosis Research Section, LCID, NIAID/NIH, 9000 Rockville Pike, Bethesda, Maryland 20892, United States

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Medical Research and Materiel Command

National Institute of Allergy and Infectious Diseases

Department of Chemistry and Biochemistry, George Mason University

Department of Chemistry, George Washington University

University Facilitating Fund, George Washington University

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.6b00125

Reference48 articles.

1. Report Reveals Scope of US Antibiotic Resistance Threat

2. The FDA Reboot of Antibiotic Development

3. Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

4. Challenges of Antibacterial Discovery

Cited by 29 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Design and synthesis of non-hydroxamate lipophilic inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR): in silico, in vitro and antibacterial studies;RSC Advances;2024

2. Inhibition of DXR in the MEP pathway with lipophilic N-alkoxyaryl FR900098 analogs;RSC Medicinal Chemistry;2024

3. New Application of cycloSaligenyl Prodrugs Approach for the Delivery of Fosfoxacin Derivatives in Mycobacteria;Molecules;2023-11-22

4. MEPicides: α,β-unsaturated Fosmidomycin N-Acyl Analogs as Efficient Inhibitors of Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate reductoisomerase;ACS Infectious Diseases;2023-06-13

5. The Multifaceted MEP Pathway: Towards New Therapeutic Perspectives;Molecules;2023-02-01