Design and synthesis of non-hydroxamate lipophilic inhibitors of 1-deoxy-<scp>d</scp>-xylulose 5-phosphate reductoisomerase (DXR): <i>in silico</i>, <i>in vitro</i> and antibacterial studies-Reference-Cited by-同舟云学术

Design and synthesis of non-hydroxamate lipophilic inhibitors of 1-deoxy-d-xylulose 5-phosphate reductoisomerase (DXR): in silico, in vitro and antibacterial studies

Published:2024 Issue:38 Volume:14 Page:27530-27554
ISSN:2046-2069
Container-title:RSC Advances
language:en
Short-container-title:RSC Adv.

Author:

Kesharwani Sharyu¹,Eeba ²,Tandi Mukesh¹,Agarwal Nisheeth²,Sundriyal Sandeep¹^ORCID

Affiliation:

1. Department of Pharmacy, Birla Institute of Technology and Science-Pilani (BITS), Pilani Campus, Vidya Vihar, Pilani, Rajasthan, 333 031, India

2. Translational Health Science and Technology Institute, NCR Biotech Science Cluster, 3rd Mile Stone, Gurugram-Faridabad Expressway, Faridabad 121001, Haryana, India

Abstract

We report the design, synthesis, and evaluation of the lipophilic DXR inhibitors as potential antimicrobial agents by replacing the hydroxamate metal-binding groups with other metal chelators.

Funder

Science and Engineering Research Board

Translational Health Science and Technology Institute

Publisher

Royal Society of Chemistry (RSC)

Link

http://pubs.rsc.org/en/content/articlepdf/2024/RA/D4RA05083E

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