Pyrazolo[1,5-a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis

Author:

Lu Xiaoyun1,Williams Zoe2,Hards Kiel23ORCID,Tang Jian45,Cheung Chen-Yi2,Aung Htin Lin23,Wang Bangxing46,Liu Zhiyong45,Hu Xianglong1,Lenaerts Anne7,Woolhiser Lisa7,Hastings Courtney7,Zhang Xiantao8,Wang Zhe9,Rhee Kyu9,Ding Ke1ORCID,Zhang Tianyu45,Cook Gregory M.23

Affiliation:

1. School of Pharmacy, Jinan University, 601 Huangpu Avenue West, Guangzhou 510632, China

2. Department of Microbiology and Immunology, School of Biomedical Sciences, University of Otago, Dunedin 9054, New Zealand

3. Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Private Bag 92019, Auckland 1042, New Zealand

4. Tuberculosis Research Laboratory, State Key Laboratory of Respiratory Disease, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, 190 Kaiyuan Avenue, Science Park, Huangpu District, Guangzhou 510530, China

5. University of Chinese Academy of Sciences (UCAS), 19 Yuquan Road, Shijingshan District, Beijing 100049, China

6. Institute of Physical Science and Information Technology, Anhui University, 111 Jiulong Road, Shushan District, Hefei 230009, China

7. Colorado State University, 200W Lake Street, Fort Collins, Colorado 80523, United States

8. Guangzhou Eggbio Co., Ltd., 3 Ju Quan Road, Science Park, Guangzhou 510663, China

9. Weill Department of Medicine, Weill Cornell Medical College, New York, New York 10021, United States

Funder

National Institute of Allergy and Infectious Diseases

Royal Society of New Zealand

Natural Science Foundation of Guangdong Province

Freemasons New Zealand

University of Otago

Maurice Wilkins Centre for Molecular Biodiscovery

Guangzhou Municipal Industry and Research Collaborative Innovation Program

Chinese Academy of Sciences Grants

Science and Technology Innovation Leader of Guangdong Province

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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