Multistage Antiplasmodium Activity of Astemizole Analogues and Inhibition of Hemozoin Formation as a Contributor to Their Mode of Action

Author:

Kumar Malkeet1,Okombo John1,Mambwe Dickson1,Taylor Dale2,Lawrence Nina2,Reader Janette3,van der Watt Mariëtte3,Fontinha Diana4,Sanches-Vaz Margarida4,Bezuidenhout Belinda C.5,Lauterbach Sonja B.5,Liebenberg Dale5,Birkholtz Lyn-Marie3,Coetzer Theresa L.5,Prudêncio Miguel4,Egan Timothy J.16ORCID,Wittlin Sergio78,Chibale Kelly169ORCID

Affiliation:

1. Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa

2. Drug Discovery and Development Centre (H3D), Division of Clinical Pharmacology, Department of Medicine, University of Cape Town, Observatory 7925, South Africa

3. Department of Biochemistry, Genetics and Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield 0028, South Africa

4. Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal

5. Department of Molecular Medicine and Haematology, School of Pathology, Faculty of Health Sciences, University of the Witwatersrand and National Health Laboratory Service, Johannesburg 2193, South Africa

6. Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch 7701, South Africa

7. Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland

8. University of Basel, 4003 Basel, Switzerland

9. South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry, University of Cape Town, Rondebosch 7701, South Africa

Funder

Department of Science and Technology, Republic of South Africa

National Research Foundation

South African Medical Research Council

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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