hERG, Plasmodium Life Cycle, and Cross Resistance Profiling of New Azabenzimidazole Analogues of Astemizole

Author:

Mambwe Dickson1ORCID,Coertzen Dina2,Leshabane Meta2,Mulubwa Mwila3,Njoroge Mathew3,Gibhard Liezl3,Girling Gareth4,Wicht Kathryn J.1ORCID,Lee Marcus C. S.45,Wittlin Sergio67,Moreira Diogo Rodrigo Magalhães8ORCID,Birkholtz Lyn-Marie2ORCID,Chibale Kelly13910ORCID

Affiliation:

1. Department of Chemistry, University of Cape Town, Rondebosch, 7701 Cape Town, South Africa

2. Department of Biochemistry, Genetics & Microbiology, Institute for Sustainable Malaria Control, University of Pretoria, Private Bag X20, Hatfield, 0028 Pretoria, South Africa

3. Drug Discovery and Development Centre (H3D), DMPK & Pharmacology, University of Cape Town, Observatory, 7925 Cape Town, South Africa

4. Wellcome Sanger Institute, Wellcome Trust Genome Campus, Hinxton CB10 1SA, United Kingdom

5. Biological Chemistry and Drug Discovery, School of Life Sciences, University of Dundee, Dundee DD1 4HN, Scotland, United Kingdom

6. Swiss Tropical and Public Health Institute, Socinstrasse 57, 4002 Basel, Switzerland

7. University of Basel, 4003 Basel, Switzerland

8. Centro de Pesquisas Gonçalo Moniz, Fundação Oswaldo Cruz (Fiocruz), Instituto Gonçalo Moniz, CEP 40296-710 Salvador, Brazil

9. South African Medical Research Council Drug Discovery and Development Research Unit, University of Cape Town, Rondebosch, 7701 Cape Town, South Africa

10. Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch, 7701 Cape Town, South Africa

Funder

Funda????o Oswaldo Cruz

Minist??rio da Ci??ncia, Tecnologia e Inova????o

University of Cape Town

National Research Foundation

South African Medical Research Council

Publisher

American Chemical Society (ACS)

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