Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors-Reference-Cited by-同舟云学术

Druggable Hot Spots in the Schistosomiasis Cathepsin B1 Target Identified by Functional and Binding Mode Analysis of Potent Vinyl Sulfone Inhibitors

Published:2020-11-11 Issue:5 Volume:7 Page:1077-1088
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Jílková Adéla¹,Rubešová Petra¹,Fanfrlík Jindřich¹,Fajtová Pavla¹,Řezáčová Pavlína¹,Brynda Jiří¹,Lepšík Martin¹^ORCID,Mertlíková-Kaiserová Helena¹,Emal Cory D.²,Renslo Adam R.³^ORCID,Roush William R.⁴^ORCID,Horn Martin¹^ORCID,Caffrey Conor R.⁵,Mareš Michael¹

Affiliation:

1. Institute of Organic Chemistry and Biochemistry, Czech Academy of Sciences, Flemingovo n. 2, 16610 Prague, Czech Republic

2. Eastern Michigan University, 541 Mark Jefferson, Ypsilanti, Michigan 48197, United States

3. University of California San Francisco, 600 16th Street, San Francisco, California 94143, United States

4. The Scripps Research Institute, 130 Scripps Way, Jupiter, Florida 33458, United States

5. Center for Discovery and Innovation in Parasitic Diseases, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California San Diego, 9500 Gilman Drive, La Jolla, California 92093, United States

Funder

European Regional Development Fund

Ministerstvo ?kolstv?, Ml?de?e a Telov?chovy

National Institute of Allergy and Infectious Diseases

Akademie Ved Cesk? Republiky

Bill and Melinda Gates Foundation

Ministerstvo Zdravotnictv? Cesk? Republiky

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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