Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma cruzi-Reference-Cited by-同舟云学术

Fragment-Based Identification of Ligands for Bromodomain-Containing Factor 3 of Trypanosoma cruzi

Published:2020-11-17 Issue:8 Volume:7 Page:2238-2249
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Laurin Corentine M. C.¹,Bluck Joseph P.¹²,Chan Anthony K. N.¹^ORCID,Keller Michelle¹,Boczek Andrew¹,Scorah Amy R.¹,See K. F. Larissa¹,Jennings Laura E.¹,Hewings David S.¹,Woodhouse Fern¹,Reynolds Jessica K.¹,Schiedel Matthias¹,Humphreys Philip G.³^ORCID,Biggin Philip C.²^ORCID,Conway Stuart J.¹^ORCID

Affiliation:

1. Department of Chemistry, Chemistry Research Laboratory, University of Oxford, Mansfield Road, Oxford OX1 3TA, UK

2. Department of Biochemistry, University of Oxford, 3 Parks Road, Oxford OX1 3QU, UK

3. GlaxoSmithKline R&D, Stevenage, Hertfordshire SG1 2NY, UK

Funder

AstraZeneca

Novartis

Defence Science and Technology Laboratory

Diamond Light Source

Pfizer

Lady Margaret Hall, University of Oxford

GlaxoSmithKline

Janssen Pharmaceuticals

Syngenta International

Engineering and Physical Sciences Research Council

Vertex Pharmaceuticals

UCB

Takeda Pharmaceutical Company

Deutsche Forschungsgemeinschaft

H2020 Marie Sklodowska-Curie Actions

St. Hugh's College, University of Oxford

Biotechnology and Biological Sciences Research Council

Evotec

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.0c00618

Reference46 articles.

1. World Health Organization (2012) Research Priorities for Chagas Disease, Human African Trypanosomiasis and Leishmaniasis, WHO Technical Report Series, Vol. 975.

2. Chagas disease

3. The Trypanosoma cruzi Proteome

4. Trypanosoma cruzi Bromodomain Factor 3 Binds Acetylated α-Tubulin and Concentrates in the Flagellum during Metacyclogenesis

5. Epigenetic protein families: a new frontier for drug discovery

Cited by 15 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Synthesis and pharmacodynamic evaluation of Dihydropteridone derivatives against PDCoV in vivo and in vitro;Bioorganic Chemistry;2024-05

2. Dynamics and Energetics of a Bromodomain in complex with bromosporine from Leishmania donovani;Revista Colombiana de Química;2024-02-05

3. Small Molecule Ligands of the BET-like Bromodomain, SmBRD3, Affect Schistosoma mansoni Survival, Oviposition, and Development;Journal of Medicinal Chemistry;2023-12-04

4. Bromodomain Factor 5 as a Target for Antileishmanial Drug Discovery;ACS Infectious Diseases;2023-10-31

5. Identification of inhibitors as drug candidates against Chagas disease;European Journal of Medicinal Chemistry;2023-02