Dibasic Benzo[b]thiophene Derivatives as a Novel Class of Active Site-Directed Thrombin Inhibitors. 1. Determination of the Serine Protease Selectivity, Structure−Activity Relationships, and Binding Orientation-Reference-Cited by-同舟云学术

Dibasic Benzo[b]thiophene Derivatives as a Novel Class of Active Site-Directed Thrombin Inhibitors. 1. Determination of the Serine Protease Selectivity, Structure−Activity Relationships, and Binding Orientation

Published:1997-10-01 Issue:22 Volume:40 Page:3489-3493
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Sall Daniel J.¹,Bastian Jolie A.¹,Briggs Stephen L.¹,Buben John A.¹,Chirgadze Nickolay Y.¹,Clawson David K.¹,Denney Michael L.¹,Giera Deborah D.¹,Gifford-Moore Donetta S.¹,Harper Richard W.¹,Hauser Kenneth L.¹,Klimkowski Valentine J.¹,Kohn Todd J.¹,Lin Ho-Shen¹,McCowan Jefferson R.¹,Palkowitz Alan D.¹,Smith Gerald F.¹,Takeuchi Kumiko¹,Thrasher Kenneth J.¹,Tinsley Jennifer M.¹,Utterback Barbara G.¹,Yan Sau-Chi B.¹,Zhang Minsheng¹

Affiliation:

1. Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, Indiana 46285

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9704107

Reference25 articles.

1. (b) Barnett, H. J. M. Thrombotic Processes in Cerebrovascular Disease.Ibid.; pp 1301−1315.

2. (c) Colman, R. W.; Cook, J. J.; Niewiarowski, S. Mechanisms of Platelet Aggregation.Ibid.; pp 508−523.

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