Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAP-K2) as an Antiinflammatory Target: Discovery and in Vivo Activity of Selective Pyrazolo[1,5-a]pyrimidine Inhibitors Using a Focused Library and Structure-Based Optimization Approach-Reference-Cited by-同舟云学术

Mitogen-Activated Protein Kinase-Activated Protein Kinase 2 (MAPKAP-K2) as an Antiinflammatory Target: Discovery and in Vivo Activity of Selective Pyrazolo[1,5-a]pyrimidine Inhibitors Using a Focused Library and Structure-Based Optimization Approach

Published:2012-07-31 Issue:15 Volume:55 Page:6700-6715
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kosugi Tomomi¹,Mitchell Dale R.²,Fujino Aiko¹,Imai Minoru¹,Kambe Mika¹,Kobayashi Shinji¹,Makino Hiroaki¹,Matsueda Yohei¹,Oue Yasuhiro¹,Komatsu Kanji¹,Imaizumi Keiichiro¹,Sakai Yuri¹,Sugiura Satoshi¹,Takenouchi Osami¹,Unoki Gen¹,Yamakoshi Yuko¹,Cunliffe Vicky²,Frearson Julie²,Gordon Richard²,Harris C. John²,Kalloo-Hosein Heidi²,Le Joelle²,Patel Gita²,Simpson Donald J.²,Sherborne Brad²,Thomas Peter S.²,Suzuki Naotaka¹,Takimoto-Kamimura Midori¹,Kataoka Ken-ichiro¹

Affiliation:

1. Teijin Institute for Bio-medical Research, Teijin Pharma Ltd., Hino, Tokyo 191-8512, Japan

2. BioFocus, Chesterford Research Park, Saffron Walden, Essex, CB10 1XL, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300411k

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1. The Future Role of Anti-Tumour Necrosis Factor (TNF) Products in the Treatment of Rheumatoid Arthritis

2. Role of Novel Biological Therapies in Psoriatic Arthritis