Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic Acid Amide Hydrochloride (CP-945,598), a Novel, Potent, and Selective Cannabinoid Type 1 Receptor Antagonist-Reference-Cited by-同舟云学术

Discovery of 1-[9-(4-Chlorophenyl)-8-(2-chlorophenyl)-9H-purin-6-yl]-4-ethylaminopiperidine-4-carboxylic Acid Amide Hydrochloride (CP-945,598), a Novel, Potent, and Selective Cannabinoid Type 1 Receptor Antagonist

Published:2008-12-22 Issue:2 Volume:52 Page:234-237
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Griffith David A.¹,Hadcock John R.¹,Black Shawn C.¹,Iredale Philip A.¹,Carpino Philip A.¹,DaSilva-Jardine Paul¹,Day Robert¹,DiBrino Joseph¹,Dow Robert L.¹,Landis Margaret S.¹,O’Connor Rebecca E.¹,Scott Dennis O.¹

Affiliation:

1. Department of Cardiovascular, Metabolic, and Endocrine Diseases and Department of Neuroscience, Pfizer Global Research and Development, Groton, Connecticut 06340

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm8012932

Reference39 articles.

1. Adipose Tissue as an Endocrine Organ

2. Endocannabinoids in the regulation of appetite and body weight

3. The Emerging Role of the Endocannabinoid System in Endocrine Regulation and Energy Balance

4. Regulation, Function, and Dysregulation of Endocannabinoids in Models of Adipose and β-Pancreatic Cells and in Obesity and Hyperglycemia

5. Low dose anandamide affects food intake, cognitive function, neurotransmitter and corticosterone levels in diet-restricted mice

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