GC-Targeted C8-Linked Pyrrolobenzodiazepine–Biaryl Conjugates with Femtomolar in Vitro Cytotoxicity and in Vivo Antitumor Activity in Mouse Models-Reference-Cited by-同舟云学术

GC-Targeted C8-Linked Pyrrolobenzodiazepine–Biaryl Conjugates with Femtomolar in Vitro Cytotoxicity and in Vivo Antitumor Activity in Mouse Models

Published:2013-03-21 Issue:7 Volume:56 Page:2911-2935
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rahman Khondaker M.¹,Jackson Paul J. M.¹,James Colin H.²,Basu B. Piku²,Hartley John A.³,de la Fuente Maria²,Schatzlein Andreas²,Robson Mathew⁴,Pedley R. Barbara⁴,Pepper Chris⁵,Fox Keith R.⁶,Howard Philip W.⁷,Thurston David E.¹

Affiliation:

1. Department of Pharmacy, Institute of Pharmaceutical Sciences, King’s College London, 150 Stamford Street, London SE1 9NH, United Kingdom

2. UCL School of Pharmacy, University College London, 29/39 Brunswick Square, London WC1N 1AX, United Kingdom

3. Cancer Research UK Drug−DNA Interactions Research Group, UCL Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6BT, United Kingdom

4. UCL Cancer Institute, University College London, Paul O’Gorman Building, 72 Huntley Street, London WC1E 6BT, United Kingdom

5. Institute of Cancer & Genetics, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom

6. Centre for Biological Sciences, University of Southampton, Southampton SO17 1BJ, United Kingdom

7. Spirogen Ltd., QMB Innovation Centre, 42 New Road, London E1 2AX, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301882a

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