Convergent Kilogram-Scale Synthesis of Dual Orexin Receptor Antagonist
Author:
Affiliation:
1. Global Process Chemistry, Merck Frosst Center for Therapeutic Research, 16711 Trans Canada Highway, Kirkland, Québec, Canada H9H 3L1
2. Global Process Chemistry, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/op3002678
Reference31 articles.
1. Orexins and Orexin Receptors: A Family of Hypothalamic Neuropeptides and G Protein-Coupled Receptors that Regulate Feeding Behavior
2. The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
3. The physiology and pharmacology of the orexins
4. Hypocretins (orexins) and sleep–wake disorders
5. Clinical and neurobiological aspects of narcolepsy
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