Evaluation and Synthesis of Polar Aryl- and Heteroaryl Spiroazetidine-Piperidine Acetamides as Ghrelin Inverse Agonists-Reference-Cited by-同舟云学术

Evaluation and Synthesis of Polar Aryl- and Heteroaryl Spiroazetidine-Piperidine Acetamides as Ghrelin Inverse Agonists

Published:2014-12-19 Issue:2 Volume:6 Page:156-161
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Orr Suvi T. M.¹,Beveridge Ramsay²,Bhattacharya Samit K.³,Cameron Kimberly O.³,Coffey Steven²,Fernando Dilinie²,Hepworth David³,Jackson Margaret V.⁴,Khot Vishal²,Kosa Rachel⁵,Lapham Kimberly⁵,Loria Paula M.⁶,McClure Kim F.³,Patel Jigna⁷,Rose Colin³,Saenz James⁷,Stock Ingrid A.⁶,Storer Gregory²,von Volkenburg Maria⁴,Vrieze Derek²,Wang Guoqiang²,Xiao Jun²,Zhang Yingxin²

Affiliation:

1. Worldwide Medicinal Chemistry, Pfizer Global Research and Development, 10770 Science Center Drive, San Diego, California 92121, United States

2. Worldwide Medicinal Chemistry, Pfizer Global Research and Development, 550 Eastern Point Road, Groton, Connecticut 06340, United States

3. Worldwide Medicinal Chemistry, Pfizer Global Research and Development, 610 Main St., Cambridge, Massachusetts 02139, United States

4. Cardiovascular and Metabolic Research Unit, Pfizer Global Research and Development, 610 Main Street, Cambridge, Massachusetts 02139, United States

5. Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, 550 Eastern Point Road, Groton, Connecticut 06340, United States

6. Primary Pharmacology Group, Pfizer Global Research and Development, 550 Eastern Point Road, Groton, Connecticut 06340, United States

7. Pharmaceutical Sciences, Pfizer Global Research and Development, 550 Eastern Point Road, Groton, Connecticut 06340, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml500414n

Reference36 articles.

1. Ghrelin Suppresses Glucose-Stimulated Insulin Secretion and Deteriorates Glucose Tolerance in Healthy Humans

2. Obesity: The Disease

3. Ghrelin is a growth-hormone-releasing acylated peptide from stomach