Novel, Potent, and Selective Quinoxaline-Based 5-HT3 Receptor Ligands. 1. Further Structure−Activity Relationships and Pharmacological Characterization-Reference-Cited by-同舟云学术

Novel, Potent, and Selective Quinoxaline-Based 5-HT3 Receptor Ligands. 1. Further Structure−Activity Relationships and Pharmacological Characterization

Published:2009-10-15 Issue:21 Volume:52 Page:6946-6950
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Butini Stefania¹²,Budriesi Roberta³,Hamon Michel⁴,Morelli Elena¹⁵,Gemma Sandra¹²,Brindisi Margherita¹²,Borrelli Giuseppe¹²,Novellino Ettore¹⁵,Fiorini Isabella¹²,Ioan Pierfranco³,Chiarini Alberto³,Cagnotto Alfredo¹⁶,Mennini Tiziana¹⁶,Fracasso Claudia¹⁶,Caccia Silvio¹⁶,Campiani Giuseppe¹²

Affiliation:

1. European Research Centre for Drug Discovery and Development, Via Banchi di Sotto 55, 53100 Siena, Italy

2. Dipartimento Farmaco Chimico Tecnologico, Università di Siena, Via Aldo Moro, 53100 Siena, Italy

3. Dipartimento di Scienze Farmaceutiche, Università di Bologna, Via Belmeloro 6, 40126 Bologna, Italy

4. Neuropsychopharmacologie, Institut National de la Santé et de la Recherche Médicale (INSERM) U. 677, Faculté de Médecine Pitié-Salpêtrière, 91, Boulevard de l’Hopital, 75634 Paris Cedex 13, France

5. Dipartimento di Chimica Farmaceutica e Tossicologica, Università di Napoli “Federico II”, Via D. Montesano 49, 80131 Napoli, Italy

6. Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156 Milano, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm901126m

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1. What do we know about serotonin?

2. Specific Targeting of Peripheral Serotonin 5-HT3 Receptors. Synthesis, Biological Investigation, and Structure−Activity Relationships

3. The 5-HT3receptor as a therapeutic target