Plasmepsin Inhibitory Activity and Structure-Guided Optimization of a Potent Hydroxyethylamine-Based Antimalarial Hit-Reference-Cited by-同舟云学术

Plasmepsin Inhibitory Activity and Structure-Guided Optimization of a Potent Hydroxyethylamine-Based Antimalarial Hit

Published:2014-01-16 Issue:4 Volume:5 Page:373-377
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Jaudzems Kristaps¹,Tars Kaspars²,Maurops Gundars¹,Ivdra Natalija¹,Otikovs Martins¹,Leitans Janis²,Kanepe-Lapsa Iveta¹,Domraceva Ilona¹,Mutule Ilze¹,Trapencieris Peteris¹,Blackman Michael J.³,Jirgensons Aigars¹

Affiliation:

1. Latvian Institute of Organic Synthesis, Aizkraukles 21, Riga LV-1006, Latvia

2. Biomedical Research and Study Centre, Ratsupites 1, Riga LV-1067, Latvia

3. Division of Parasitology, MRC National Institute for Medical Research, The Ridgeway, Mill, Hill, London NW7 1AA, U.K.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ml4004952

Reference22 articles.

1. WHO. World Malaria Report 2012;World Health Organization:Geneva, Switzerland, 2012; p59.

2. Drug-resistant malaria − an insight

3. The Fight Against Drug-Resistant Malaria: Novel Plasmodial Targets and Antimalarial Drugs

4. New medicines to improve control and contribute to the eradication of malaria

5. ChEMBL-NTD.https://www.ebi.ac.uk/chemblntd(accessed Aug 16,2013).

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