Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8-Reference-Cited by-同舟云学术

Discovery of a Selective, Substrate-Competitive Inhibitor of the Lysine Methyltransferase SETD8

Published:2014-07-25 Issue:15 Volume:57 Page:6822-6833
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Ma Anqi,Yu Wenyu¹,Li Fengling¹,Bleich Rachel M.,Herold J. Martin,Butler Kyle V.,Norris Jacqueline L.,Korboukh Victoria,Tripathy Ashutosh,Janzen William P.,Arrowsmith Cheryl H.¹,Frye Stephen V.,Vedadi Masoud¹²,Brown Peter J.¹,Jin Jian

Affiliation:

1. Structural Genomics Consortium, University of Toronto, Toronto, Ontario M5G 1L7, Canada

2. Department of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario M5S 1A8, Canada

Funder

V Foundation for Cancer Research

Structural Genomics Consortium

University Cancer Research Fund, University of North Carolina - Chapel Hill

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm500871s

Reference53 articles.

1. Protein methyltransferases as a target class for drug discovery

2. Epigenetic protein families: a new frontier for drug discovery

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5. Chromatin Modifications and Their Function

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