Further Studies on Imidazo[4,5-b]pyridine AT1 Angiotensin II Receptor Antagonists. Effects of the Transformation of the 4-Phenylquinoline Backbone into 4-Phenylisoquinolinone or 1-Phenylindene Scaffolds-Reference-Cited by-同舟云学术

Further Studies on Imidazo[4,5-b]pyridine AT1 Angiotensin II Receptor Antagonists. Effects of the Transformation of the 4-Phenylquinoline Backbone into 4-Phenylisoquinolinone or 1-Phenylindene Scaffolds

Published:2006-10-06 Issue:22 Volume:49 Page:6451-6464
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Cappelli Andrea¹,Pericot Mohr Gal.la¹,Giuliani Germano¹,Galeazzi Simone¹,Anzini Maurizio¹,Mennuni Laura¹,Ferrari Flora¹,Makovec Francesco¹,Kleinrath Eva M.¹,Langer Thierry¹,Valoti Massimo¹,Giorgi Gianluca¹,Vomero Salvatore¹

Affiliation:

1. Dipartimento Farmaco Chimico Tecnologico and European Research Centre for Drug Discovery and Development, Università di Siena, Via A. Moro, 53100 Siena, Italy, Rotta Research Laboratorium S.p.A., Via Valosa di Sopra 7, 20052 Monza, Italy, Department of Pharmaceutical Chemistry, Institute of Pharmacy, University of Innsbruck, Innrain 52a, A-6020 Innsbruck, Austria, Dipartimento di Scienze Biomediche, Università di Siena, Via A. Moro, 53100 Siena, Italy, and Dipartimento di Chimica, Università di Siena,...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0603163

Reference36 articles.

1. A review of mutagenesis studies of angiotensin II type 1 receptor, the three-dimensional receptor model in search of the agonist and antagonist binding site and the hypothesis of a receptor activation mechanism

2. Nonpeptide Angiotensin II Receptor Antagonists: The Next Generation in Antihypertensive Therapy

3. Potent, orally active imidazo[4,5-b]pyridine-based angiotensin II receptor antagonists

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