The Discovery of N-((2H-Tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): A Potent and Selective Glucagon Receptor Antagonist-Reference-Cited by-同舟云学术

The Discovery of N-((2H-Tetrazol-5-yl)methyl)-4-((R)-1-((5r,8R)-8-(tert-butyl)-3-(3,5-dichlorophenyl)-2-oxo-1,4-diazaspiro[4.5]dec-3-en-1-yl)-4,4-dimethylpentyl)benzamide (SCH 900822): A Potent and Selective Glucagon Receptor Antagonist

Published:2014-02-26 Issue:6 Volume:57 Page:2601-2610
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

DeMong Duane¹,Dai Xing¹,Hwa Joyce¹,Miller Michael¹,Lin Sue-Ing¹,Kang Ling¹,Stamford Andrew¹,Greenlee William¹,Yu Wensheng¹,Wong Michael¹,Lavey Brian¹,Kozlowski Joseph¹,Zhou Guowei¹,Yang De-Yi¹,Patel Bhuneshwari¹,Soriano Aileen¹,Zhai Ying¹,Sondey Christopher¹,Zhang Hongtao¹,Lachowicz Jean¹,Grotz Diane¹,Cox Kathleen¹,Morrison Richard¹,Andreani Teresa¹,Cao Yang¹,Liang Mark¹,Meng Tao¹,McNamara Paul¹,Wong Jesse¹,Bradley Prudence¹,Feng Kung-I¹,Belani Jitendra²,Chen Ping²,Dai Peng²,Gauuan Jolicia²,Lin Peishan²,Zhao He²

Affiliation:

1. Discovery and Preclinical Sciences, Merck Research Laboratories, 2015 Galloping Hill Road, Kenilworth, New Jersey 07033, United States

2. Medicinal Chemistry Department, AMRI, 26 Corporate Circle, P.O. Box 15098, Albany, New York 12212-5098, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm401858f

Reference30 articles.

1. AQUEOUS EXTRACTS OF PANCREAS

2. The Amino Acid Sequence of Glucagon. V. Location of Amide Groups, Acid Degradation Studies and Summary of Sequential Evidence