Imidazolone as an Amide Bioisostere in the Development of β-1,3-<i>N</i>-Acetylglucosaminyltransferase 2 (B3GNT2) Inhibitors-Reference-Cited by-同舟云学术

Imidazolone as an Amide Bioisostere in the Development of β-1,3-N-Acetylglucosaminyltransferase 2 (B3GNT2) Inhibitors

Published:2023-11-21 Issue:23 Volume:66 Page:16120-16140
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Jackson Jeffrey J.¹^ORCID,Siegmund Aaron C.¹,Bai Wen-Ju¹^ORCID,Reed Anthony B.¹,Birkholz Adam B.²^ORCID,Campuzano Iain D. G.²^ORCID,Créquer-Grandhomme Amandine³,Hu Ruozhen³,Modak Rucha V.³,Sudom Athena¹,Javier Noelle⁴,Sanders Christiana⁵,Lo Mei-Chu⁴,Xie Fang⁶,Cee Victor J.¹^ORCID,Manzanillo Paolo³,Allen John G.¹

Affiliation:

1. Small Molecule Therapeutic Discovery, Amgen Research, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States

2. Center for Research Acceleration by Digital Innovation, Amgen Research, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States

3. Inflammation, Amgen Research, Amgen Inc., 750 Gateway Blvd, Ste 100, South San Francisco, California 94080, United States

4. Lead Discovery & Characterization, Amgen Research, Amgen Inc., 750 Gateway Blvd, Ste 100, South San Francisco, California 94080, United States

5. Lead Discovery & Characterization, Amgen Research, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, United States

6. Pharmacokinetics & Drug Metabolism, Amgen Research, Amgen Inc., 750 Gateway Blvd, Ste 100, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.jmedchem.3c01517

Reference44 articles.

1. ISOMORPHISM, ISOSTERISM AND COVALENCE.

2. Friedman, H. L. Influence of Isosteric Replacements upon Biological Activity; NAS-NRS Publication, 1951; Vol. 206, pp 295–358.

3. Bioisosterism: A Rational Approach in Drug Design

4. Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

5. Amide Bond Bioisosteres: Strategies, Synthesis, and Successes

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